Serena Beuford was working out with her friend who was filming Beuford squatting for her Instagram account.
As the 27-year-old was squatting she heard a loud pop which caused her to stop the exercise.
But soon after Beuford was on the floor screaming in agony.
Doctors say the Boston woman is in a serious condition after she was rushed to the hospital where she slipped into a coma.
One gym member said that she heard "a loud popping noise".
She said: "She was screaming my a** is gone!
"I had no idea what she was talking about until I saw her cushion like butt missing."
According to Beuford's sister Jackie, she had visited an unlicensed clinic to get the 64-inch bum - because she wanted to be famous on Instagram.
She said: "She started to become famous on Instagram and even got a job at a club.
"Guys would look at her differently and buy her expensive stuff just because of her butt."
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